MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, encoded by the mitochondrial genome. It plays a critical role in cellular metabolic regulation and energy homeostasis. MOTS-c is unique among mitochondrial-derived peptides (MDPs) due to its ability to translocate to the nucleus during metabolic stress, where it regulates the expression of nuclear genes related to mitochondrial biogenesis, antioxidant responses, and metabolic adaptation.
Research:
1.
METTEN study: A phase 2 clinical trial exploring the impact of metformin on circulating MOTS-c levels in women with breast cancer (EudraCT number 2011-000490-30).
2.
CB4211 Phase 1a trial: A double-blind, placebo-controlled single ascending dose and multiple ascending dose clinical trial testing the MOTS-c peptide analog CB4211.
Product Care:
Store in a cool, dry place away from light. If Constituted, Please Refrigerate. For longer term storage, freezing at -20°C is recommended to maintain integrity.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Resources
Disclaimer & Notice of Usage - Research Purposes Only
The information provided here is for research purposes only. It is not an endorsement or recommendation for using peptides outside of a laboratory setting. Every detail—including descriptions of specific peptides and their studied benefits—is offered solely for informational purposes. This content should not be interpreted as medical, clinical, or legal advice, nor as encouragement for non-research applications in humans. The peptides discussed are intended exclusively for controlled scientific studies performed by qualified professionals. We strongly recommend consulting with research experts, healthcare providers, or legal advisors before making any decisions regarding the acquisition or use of these peptides. Responsible and ethical use of this information for legitimate academic and investigative purposes is essential. This notice governs all content related to research peptides and may be updated as needed.